Diş Hekimliği

Canlılarda kendilerini yenileme ve farklılaşma (plastisite) kabiliyeti bulunan hücrelere kök hücre denir. Bu önemli öngörü Alman bilim adam  Carl Rudolph Wirchow'un 1800'lü yılların başındaki "Omnis cellula e cellula = tüm hücreler başka hücrelerden gelişir" yaklaşımıdır. Bu yaklaşımdan yola c kan  Harvest BMAC2 sistemi ile “point-of-care“ olarak siz hekimlerimizin kullanımına sunulmuştur.

KULLANIM ALANLARI

  • Dental implantlar için kemik greftleme: Bu onlay ve inlay greftleri sinüs kaldırma işlemi, çene  kemiği geni şletme işlemi.
  • Sinüs boşluğu ve ağız boşluğu arasında oluşan kanalın (fistül) tamiri

LITERATUR

  • IN VIVO ASSESSMENT OF INTEGRATION OF MSCS TRANS-PLANTED ON IOMATERIAL SCAFFOLDS BY DYNAMIC CON-TRAST-ENHANCED MRI

Sebastian Sauerbier1 DMD, Moritz Palmowski2 DMD, , Heiner

 Results

It is possible to observe the transformation of the transplanted biomater-ial in the T1-weighted images.A hypointense region at the rim of the transplant is growing to the centre with increasing time after the surgery.In the post CM images the corresponding regions show enhancement.
The dynamic curves of the mean CM-concentration in the sinus-ROI show simultaneously to a drastically increasing CMuptake after the surgery an alteration of the shape. Compared to non effected muscle tissue iAUC60, ktrans and ve of the sinus-ROI start with a lower value before the surgery, but cross the musclelevel later on reaching a considerable higher value 104 days after the transplantation. Pixelmaps show increasing perfusion from the rim to the centre of the transplant with increasing time after the surgery


(Fig.1). The right and left side of the sinus turn out to vary in size and progress. The MRI findings correlate to histological parameters.
 
In Vivo Comparison of Hard Tissue Regeneration with Human Mesenchymal Stem Cells Processed with Either the FICOLL Method or the BMAC Method Sebastian Sauerbier, M.D.,1,* Andres Stricker, M.D., D.D.S.,1,* Jens Kuschnierz, M.D., D.D.S.,1 Felicia Bu¨ hler, D.D.S.,1 Toshiyuki Oshima, D.M.D.,1,2 Samuel Porfirio Xavier, D.D.S.,3 Rainer

  • In Vivo Comparison of Hard Tissue Regeneration withHuman Mesenchymal Stem Cells Processed with Either the FICOLL Method or the BMAC Method
    Sebastian Sauerbier, M.D.,1,* Andres Stricker, M.D., D.D.S.,1,* Jens Kuschnierz, M.D., D.D.S.,1 Felicia Bu¨ hler, D.D.S.,1 Toshiyuki Oshima, D.M.D.,1,2 Samuel Porfirio Xavier, D.D.S.,3 Rainer Schmelzeisen, M.D., D.D.S.,1 and Ralf Gutwald, M.D., D.D.S.

Conclusion

The FICOLL and the BMAC group showed comparable new bone formation. When autologous thrombin is used, a denser packing of biomaterial is possible than when cells are applied with the thrombin component of commercially available fibrin glue. This leads to a higher proportion of hard tissue in the BMAC group. The BMAC system is effective and suited for chair-side application. For a broad clinical application of
this minimal invasive method a randomized controlled trial with a closed chair-side system is needed for further evaluation. In general, there is a lack of in vivo comparisons of different BMA-processing methods.

Short communication Making boneII: maxillarysinusaugmen-tationwith mononuclear cells—casereportwithanewclinical-method

RainerSchmelzeisen,RalfGutwald,ToshiyukiOshima,HeinerNagursky,Michael Vogeler,SebastianSauerbier, Department of Oral and Cranio maxill ofacial Surgery, University Hospital Freiburg, Hugstetter Str.55,D 79106Freiburg,Germany Discussion The combination of BBM and BMAC seems to resultin quicker formation of bone, as  previously reported  sinus augmentation with BBM and venous blood showed bony formation of 14.7% after  healing time of 6–8 months.